| 1. Jornada | 09.01.2022 | Santos Laguna [Sub 16] | - | CF Monterrey [Sub 16] | 0:0 | ||||
| 3. Jornada | 22.01.2022 | UANL Tigres [Sub 16] | - | Santos Laguna [Sub 16] | 0:2 | ||||
| 6. Jornada | 12.02.2022 | Santos Laguna [Sub 16] | - | Atlas Guadalajara [Sub 16] | 5:3 | ||||
| 7. Jornada | 18.02.2022 | Club León [Sub 16] | - | Santos Laguna [Sub 16] | 0:0 | ||||
| 18. Jornada | 07.05.2022 | Santos Laguna [Sub 16] | - | Club León [Sub 16] | 2:1 |
México