| 1. Jornada | 18.09.2021 | Tuzos de la UAZ | - | Saltillo FC | 1:1 |  |
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| 2. Jornada | 27.09.2021 | Saltillo FC | - | Alacranes de Durango | 1:1 | ||||
| 3. Jornada | 02.10.2021 | Cimarrones de Sonora II | - | Saltillo FC | 2:2 | |
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| 4. Jornada | 09.10.2021 | Saltillo FC | - | Correcaminos UAT II | 1:0 | ||||
| 5. Jornada | 13.10.2021 | Saltillo FC | - | Tritones Vallarta | 2:0 | ||||
| 6. Jornada | 16.10.2021 | Catedráticos Elite | - | Saltillo FC | 1:0 | |
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| 7. Jornada | 23.10.2021 | Saltillo FC | - | Gavilanes de Matamoros | 3:1 | ||||
| 8. Jornada | 31.10.2021 | Mazorqueros | - | Saltillo FC | 1:2 | ||||
| 9. Jornada | 06.11.2021 | Saltillo FC | - | Tecos Fútbol Club | 3:1 | ||||
| 10. Jornada | 11.11.2021 | Colima FC | - | Saltillo FC | 1:2 | ||||
| 11. Jornada | 13.11.2021 | Saltillo FC | - | Leones Negros II | 3:1 | ||||
| 12. Jornada | 20.11.2021 | Coras de Nayarit | - | Saltillo FC | 0:1 | ||||
| 13. Jornada | 27.11.2021 | Saltillo FC | - | Mineros de Fresnillo FC | 4:2 |
México