| 6. Jornada | 16.09.2021 | Sporting Kansas City | - | Minnesota United FC | 4:0 | ||||
| 6. Jornada | 19.09.2021 | Minnesota United FC | - | Los Angeles Galaxy | 3:0 | ||||
| 6. Jornada | 30.09.2021 | D.C. United | - | Minnesota United FC | 3:1 | ||||
| 7. Jornada | 17.10.2021 | Austin FC | - | Minnesota United FC | 0:1 | ||||
| 7. Jornada | 21.10.2021 | Minnesota United FC | - | Philadelphia Union | 3:2 | ||||
| 7. Jornada | 28.10.2021 | Vancouver Whitecaps | - | Minnesota United FC | 2:1 |
Honduras