| 6. Jornada | 13.09.2021 | FC Eindhoven | - | Helmond Sport | 3:2 | ||||
| 7. Jornada | 17.09.2021 | Helmond Sport | - | FC Utrecht (J) | 0:3 | ||||
| 9. Jornada | 01.10.2021 | Helmond Sport | - | Jong Ajax | 3:1 |  |
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| 10. Jornada | 10.10.2021 | FC Dordrecht | - | Helmond Sport | 0:1 | ||||
| 11. Jornada | 15.10.2021 | Helmond Sport | - | ADO Den Haag | 0:0 | ||||
| 12. Jornada | 22.10.2021 | Telstar | - | Helmond Sport | 2:2 | ||||
| 13. Jornada | 01.11.2021 | Helmond Sport | - | Almere City FC | 1:2 |  |
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| 17. Jornada | 27.11.2021 | NAC Breda | - | Helmond Sport | 1:0 |
Bélgica