| 1. Jornada | 24.04.2021 | Toronto FC | - | Vancouver Whitecaps | 2:2 | ||||
| 2. Jornada | 13.05.2021 | Toronto FC | - | Columbus Crew | 2:0 |  |
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| 2. Jornada | 15.05.2021 | New York City FC | - | Toronto FC | 1:1 | ||||
| 2. Jornada | 23.05.2021 | Orlando City | - | Toronto FC | 1:0 | ||||
| 4. Jornada | 18.07.2021 | Toronto FC | - | Orlando City | 1:1 | |
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| 4. Jornada | 22.07.2021 | Toronto FC | - | New York RB | 1:1 | ||||
| 4. Jornada | 25.07.2021 | Chicago Fire | - | Toronto FC | 1:2 | ||||
| 5. Jornada | 02.08.2021 | Toronto FC | - | Nashville SC | 1:1 | ||||
| 5. Jornada | 05.08.2021 | Philadelphia Union | - | Toronto FC | 3:0 | ||||
| 5. Jornada | 08.08.2021 | Toronto FC | - | New York City FC | 2:2 | ||||
| 7. Jornada | 17.10.2021 | Toronto FC | - | Atlanta United FC | 0:2 | ||||
| 7. Jornada | 21.10.2021 | Inter Miami CF | - | Toronto FC | 3:0 | ||||
| 7. Jornada | 24.10.2021 | Toronto FC | - | CF Montréal | 1:1 | |
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| 7. Jornada | 28.10.2021 | Toronto FC | - | Philadelphia Union | 2:2 | |
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| 7. Jornada | 31.10.2021 | Atlanta United FC | - | Toronto FC | 1:1 | ||||
| 8. Jornada | 07.11.2021 | Toronto FC | - | D.C. United | 1:3 |
Estados Unidos
Haití 
