| 2. Jornada | 29.01.2016 | Club Rubio Ñu | - | Club Nacional | 2:1 |  |
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| 5. Jornada | 14.02.2016 | Club Nacional | - | Libertad | 1:3 | ||||
| 6. Jornada | 20.02.2016 | Club Nacional | - | River Plate | 0:0 | |
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| 7. Jornada | 27.02.2016 | Deportivo Capiatá | - | Club Nacional | 2:4 |  |
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| 8. Jornada | 03.03.2016 | Club Nacional | - | General Díaz | 1:3 | |
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| 9. Jornada | 06.03.2016 | Cerro Porteño | - | Club Nacional | 1:2 | ||||
| 10. Jornada | 12.03.2016 | Club Nacional | - | Sportivo Luqueño | 1:1 | ||||
| 11. Jornada | 20.03.2016 | General Caballero ZC | - | Club Nacional | 1:3 | |
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| 12. Jornada | 03.04.2016 | Guaraní | - | Club Nacional | 1:0 | ||||
| 13. Jornada | 07.04.2016 | Club Nacional | - | Club Rubio Ñu | 3:1 | ||||
| 14. Jornada | 10.04.2016 | Club Olimpia | - | Club Nacional | 3:1 | ||||
| 16. Jornada | 21.04.2016 | Libertad | - | Club Nacional | 4:3 | ||||
| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 18. Jornada | 30.04.2016 | Club Nacional | - | Deportivo Capiatá | 0:1 | ||||
| 19. Jornada | 05.05.2016 | General Díaz | - | Club Nacional | 1:1 | ||||
| 21. Jornada | 14.05.2016 | Sportivo Luqueño | - | Club Nacional | 3:2 | ||||
| 22. Jornada | 22.05.2016 | Club Nacional | - | General Caballero ZC | 2:3 |
Paraguay