| 4. Jornada | 21.08.2005 | Pumas UNAM | - | Club San Luis | 0:0 | ||||
| 5. Jornada | 25.08.2005 | Club San Luis | - | Atlante | 2:2 | ||||
| 6. Jornada | 28.08.2005 | UANL Tigres | - | Club San Luis | 1:0 |  |
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| 7. Jornada | 11.09.2005 | Club San Luis | - | Dorados de Sinaloa | 4:1 |  |
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| 8. Jornada | 18.09.2005 | Santos Laguna | - | Club San Luis | 3:1 |  |
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| 10. Jornada | 29.09.2005 | Club Necaxa | - | Club San Luis | 2:1 | |
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| 11. Jornada | 02.10.2005 | CF América | - | Club San Luis | 3:1 | |
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| 12. Jornada | 16.10.2005 | Club San Luis | - | Veracruz (old) | 1:0 | ||||
| 13. Jornada | 23.10.2005 | Cruz Azul | - | Club San Luis | 3:0 | ||||
| 14. Jornada | 30.10.2005 | Club San Luis | - | CF Monterrey | 1:2 | |
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| 15. Jornada | 06.11.2005 | CF Pachuca | - | Club San Luis | 0:0 | ||||
| 16. Jornada | 20.11.2005 | Club San Luis | - | Monarcas Morelia | 2:1 | |
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