| 1. Jornada | 13.08.2021 | Hamrun Spartans | - | Valletta FC | 1:2 |  |
|||
| 2. Jornada | 21.08.2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | ||||
| 3. Jornada | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 | ||||
| 6. Jornada | 16.10.2021 | Hamrun Spartans | - | Gżira United | 0:1 | ||||
| 7. Jornada | 23.10.2021 | Gudja United | - | Hamrun Spartans | 1:3 | ||||
| 8. Jornada | 30.10.2021 | Hamrun Spartans | - | Sirens FC | 1:0 | ||||
| 12. Jornada | 13.12.2021 | Valletta FC | - | Hamrun Spartans | 0:1 | ||||
| 15. Jornada | 22.01.2022 | Balzan FC | - | Hamrun Spartans | 2:2 | ||||
| 13. Jornada | 26.01.2022 | Hamrun Spartans | - | Birkirkara FC | 0:0 | ||||
| 20. Jornada | 26.02.2022 | Hamrun Spartans | - | Hibernians FC | 0:0 | ||||
| 21. Jornada | 06.03.2022 | St. Luċija FC | - | Hamrun Spartans | 0:1 | ||||
| 22. Jornada | 11.03.2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
Malta