| 3. Jornada | 20.01.2013 | Club San Luis | - | Monarcas Morelia | 1:2 | ||||
| 4. Jornada | 27.01.2013 | CF Monterrey | - | Club San Luis | 3:2 | ||||
| 6. Jornada | 10.02.2013 | Club San Luis | - | Puebla FC | 1:3 | ||||
| 7. Jornada | 17.02.2013 | Club León | - | Club San Luis | 2:0 | ||||
| 8. Jornada | 24.02.2013 | Club San Luis | - | Pumas UNAM | 0:2 |  |
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| 9. Jornada | 03.03.2013 | CF Pachuca | - | Club San Luis | 2:1 | ||||
| 10. Jornada | 10.03.2013 | Club San Luis | - | UANL Tigres | 1:2 | |
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| 11. Jornada | 17.03.2013 | CF América | - | Club San Luis | 1:1 |  |
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| 12. Jornada | 31.03.2013 | Club San Luis | - | Jaguares Chiapas | 3:0 | |
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| 13. Jornada | 08.04.2013 | Atlante | - | Club San Luis | 0:1 | ||||
| 14. Jornada | 14.04.2013 | Club San Luis | - | Atlas Guadalajara | 2:2 | |
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| 15. Jornada | 21.04.2013 | Gallos Blancos (old) | - | Club San Luis | 2:1 | ||||
| 16. Jornada | 28.04.2013 | Club San Luis | - | Club Tijuana | 1:0 | |
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| 17. Jornada | 05.05.2013 | Deportivo Toluca | - | Club San Luis | 0:1 |
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