| 1. Jornada | 09.01.2021 | Club Tijuana | - | Pumas UNAM | 0:0 | ||||
| 2. Jornada | 17.01.2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
| 7. Jornada | 21.02.2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 8. Jornada | 01.03.2021 | Deportivo Guadalajara | - | Pumas UNAM | 2:1 | ||||
| 9. Jornada | 05.03.2021 | Pumas UNAM | - | Santos Laguna | 1:0 |  |
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| 10. Jornada | 08.03.2021 | Pumas UNAM | - | Cruz Azul | 0:1 | |
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| 11. Jornada | 13.03.2021 | FC Juárez | - | Pumas UNAM | 1:1 | |
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| 12. Jornada | 21.03.2021 | Atlético San Luis | - | Pumas UNAM | 0:1 | |
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| 13. Jornada | 04.04.2021 | Pumas UNAM | - | CF Pachuca | 2:2 | |
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| 14. Jornada | 10.04.2021 | Club Necaxa | - | Pumas UNAM | 0:1 | |
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| 15. Jornada | 18.04.2021 | Pumas UNAM | - | UANL Tigres | 0:0 | ||||
| 16. Jornada | 24.04.2021 | Puebla FC | - | Pumas UNAM | 0:0 | ||||
| 17. Jornada | 03.05.2021 | Pumas UNAM | - | CF América | 0:1 |
Argentina
Italia 
