| 13. Jornada | 16.10.2021 | Atlas Guadalajara [Sub 16] | - | Club Necaxa [Sub 16] | 1:4 | ||||
| 14. Jornada | 23.10.2021 | Club Necaxa [Sub 16] | - | Atlético San Luis [Sub 16] | 4:0 | ||||
| 15. Jornada | 30.10.2021 | Santos Laguna [Sub 16] | - | Club Necaxa [Sub 16] | 2:1 | ||||
| 16. Jornada | 06.11.2021 | Club Necaxa [Sub 16] | - | Club León [Sub 16] | 0:1 |  |
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| 17. Jornada | 13.11.2021 | Mazatlán FC [Sub 16] | - | Club Necaxa [Sub 16] | 2:1 | ||||
| 18. Jornada | 20.11.2021 | Club Necaxa [Sub 16] | - | CF Monterrey [Sub 16] | 1:1 |
México