| 1. Jornada | 12.01.2025 | Caja Oblatos | - | Santiago FC | 2:1 | ||||
| 2. Jornada | 18.01.2025 | Santiago FC | - | CD Ayense | 3:2 | ||||
| 3. Jornada | 25.01.2025 | Cordobés FC | - | Santiago FC | 2:0 | ||||
| 5. Jornada | 08.02.2025 | Santiago FC | - | Artesanos Metepec | 3:0 | ||||
| 6. Jornada | 14.02.2025 | Real Zamora | - | Santiago FC | 1:2 | ||||
| 7. Jornada | 22.02.2025 | Santiago FC | - | Poza Rica | 4:1 |  |
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| 8. Jornada | 01.03.2025 | Club de Ciervos | - | Santiago FC | 0:3 | |
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| 9. Jornada | 08.03.2025 | Santiago FC | - | CDM FC | 1:1 | |
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| 10. Jornada | 14.03.2025 | Atlético Pachuca | - | Santiago FC | 0:0 | ||||
| 13. Jornada | 05.04.2025 | Santiago FC | - | Cañoneros FC | 2:1 |
México