| 1. Jornada | 12.02.2022 | Banfield II | - | San Lorenzo II | 2:1 |  |
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| 2. Jornada | 16.02.2022 | Gimnasia de La Plata II | - | San Lorenzo II | 2:1 | ||||
| 3. Jornada | 21.02.2022 | San Lorenzo II | - | Defensa y Justicia II | 0:4 | ||||
| 4. Jornada | 26.02.2022 | Argentinos Juniors II | - | San Lorenzo II | 2:0 | ||||
| 5. Jornada | 04.03.2022 | San Lorenzo II | - | River Plate II | 0:4 | ||||
| 6. Jornada | 12.03.2022 | Talleres de Córdoba II | - | San Lorenzo II | 2:3 | ||||
| 7. Jornada | 21.03.2022 | San Lorenzo II | - | Huracán II | 0:0 | ||||
| 8. Jornada | 04.04.2022 | San Lorenzo II | - | Atlético Tucumán II | 1:1 | ||||
| 10. Jornada | 15.04.2022 | San Lorenzo II | - | Platense II | 1:1 | ||||
| 11. Jornada | 20.04.2022 | Unión de Santa Fe II | - | San Lorenzo II | 1:4 | |
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| 13. Jornada | 30.04.2022 | Newell's Old Boys II | - | San Lorenzo II | 0:3 | ||||
| 14. Jornada | 09.05.2022 | San Lorenzo II | - | Racing Club II | 3:1 |
Argentina