| 5. Jornada | 12.02.2022 | Deportivo Guadalajara [Sub 20] | - | UANL Tigres [Sub 20] | 0:1 |  |
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| 6. Jornada | 19.02.2022 | UANL Tigres [Sub 20] | - | Atlético San Luis [Sub 20] | 1:1 | ||||
| 7. Jornada | 25.02.2022 | FC Juárez [Sub 20] | - | UANL Tigres [Sub 20] | 0:4 | ||||
| 8. Jornada | 02.03.2022 | UANL Tigres [Sub 20] | - | Cruz Azul [Sub 20] | 1:1 | ||||
| 10. Jornada | 12.03.2022 | Club León [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 | |
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| 11. Jornada | 19.03.2022 | UANL Tigres [Sub 20] | - | CF Monterrey [Sub 20] | 0:1 |
México