| 5. Jornada | 04.03.2022 | Central Córdoba SdE | - | Rosario Central | 0:1 | ||||
| 6. Jornada | 12.03.2022 | Rosario Central | - | Barracas Central | 1:3 | ||||
| 7. Jornada | 20.03.2022 | Rosario Central | - | Newell's Old Boys | 0:1 | ||||
| 8. Jornada | 04.04.2022 | Tigre | - | Rosario Central | 2:0 | ||||
| 9. Jornada | 09.04.2022 | Rosario Central | - | Colón de Santa Fe | 2:2 | ||||
| 10. Jornada | 16.04.2022 | Aldosivi | - | Rosario Central | 1:0 | ||||
| 11. Jornada | 21.04.2022 | CA Lanús | - | Rosario Central | 3:1 | ||||
| 12. Jornada | 23.04.2022 | Rosario Central | - | Independiente | 3:0 | ||||
| 13. Jornada | 03.05.2022 | Huracán | - | Rosario Central | 2:1 |  |
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| 14. Jornada | 08.05.2022 | Rosario Central | - | Estudiantes | 3:1 |
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