| 3. Jornada | 20.02.2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 |  |
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| 8. Jornada | 21.03.2022 | Tauro FC | - | San Francisco FC | 1:0 | ||||
| 9. Jornada | 26.03.2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 12. Jornada | 05.05.2022 | Veraguas United | - | San Francisco FC | 0:2 | ||||
| 16. Jornada | 08.05.2022 | San Francisco FC | - | Herrera FC | 3:1 |
Panamá