| 9. Jornada | 21.02.2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 |  |
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| 10. Jornada | 01.03.2021 | AD San Carlos | - | Limón FC | 0:3 | ||||
| 11. Jornada | 04.03.2021 | Deportivo Saprissa | - | AD San Carlos | 1:1 | ||||
| 12. Jornada | 08.03.2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 13. Jornada | 13.03.2021 | CS Herediano | - | AD San Carlos | 0:1 | ||||
| 14. Jornada | 21.03.2021 | Guadalupe | - | AD San Carlos | 1:2 | ||||
| 16. Jornada | 05.04.2021 | Sporting FC | - | AD San Carlos | 2:0 | ||||
| 17. Jornada | 10.04.2021 | CS Cartaginés | - | AD San Carlos | 1:1 |  |
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| 18. Jornada | 19.04.2021 | AD San Carlos | - | Santos de Guápiles | 1:0 | |
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| 19. Jornada | 22.04.2021 | Municipal Grecia | - | AD San Carlos | 2:1 | ||||
| 20. Jornada | 27.04.2021 | AD San Carlos | - | Municipal Pérez Zeledón | 0:1 | ||||
| 21. Jornada | 01.05.2021 | Limón FC | - | AD San Carlos | 0:3 | |
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| 22. Jornada | 13.05.2021 | AD San Carlos | - | Deportivo Saprissa | 2:0 |
Costa Rica
Nicaragua