| 1. Jornada | 12.01.2022 | Santos Laguna [Sub 18] | - | UANL Tigres [Sub 18] | 5:0 | ||||
| 2. Jornada | 15.01.2022 | UANL Tigres [Sub 18] | - | Puebla FC [Sub 18] | 1:0 | ||||
| 3. Jornada | 23.01.2022 | Pumas UNAM [Sub 18] | - | UANL Tigres [Sub 18] | 1:4 |  |
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| 4. Jornada | 06.02.2022 | UANL Tigres [Sub 18] | - | Mazatlán FC [Sub 18] | 3:3 |  |
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| 5. Jornada | 12.02.2022 | Deportivo Guadalajara [Sub 18] | - | UANL Tigres [Sub 18] | 3:0 | ||||
| 6. Jornada | 19.02.2022 | UANL Tigres [Sub 18] | - | Atlético San Luis [Sub 18] | 0:1 | |
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| 7. Jornada | 25.02.2022 | FC Juárez [Sub 18] | - | UANL Tigres [Sub 18] | 2:2 | ||||
| 8. Jornada | 02.03.2022 | UANL Tigres [Sub 18] | - | Cruz Azul [Sub 18] | 2:0 | ||||
| 10. Jornada | 12.03.2022 | Club León [Sub 18] | - | UANL Tigres [Sub 18] | 2:1 | ||||
| 11. Jornada | 19.03.2022 | UANL Tigres [Sub 18] | - | CF Monterrey [Sub 18] | 0:4 | |
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| 9. Jornada | 23.03.2022 | CF Pachuca [Sub 18] | - | UANL Tigres [Sub 18] | 4:0 |
México