| 1. Jornada | 29.07.2021 | CF Monterrey II | - | Cancún FC | 1:2 | ||||
| 2. Jornada | 09.08.2021 | Atlante | - | CF Monterrey II | 2:1 |  |
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| 3. Jornada | 14.08.2021 | CF Monterrey II | - | Tapatío | 2:0 | ||||
| 4. Jornada | 18.08.2021 | Venados FC | - | CF Monterrey II | 1:1 |  |
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| 5. Jornada | 26.08.2021 | CF Monterrey II | - | Club Celaya | 1:0 | ||||
| 6. Jornada | 02.09.2021 | Alebrijes de Oaxaca | - | CF Monterrey II | 0:0 | ||||
| 7. Jornada | 08.09.2021 | CF Monterrey II | - | TM Fútbol Club | 0:0 | ||||
| 8. Jornada | 16.09.2021 | Cimarrones de Sonora | - | CF Monterrey II | 1:2 | ||||
| 9. Jornada | 22.09.2021 | CF Monterrey II | - | Mineros de Zacatecas | 0:1 | ||||
| 10. Jornada | 29.09.2021 | Tepatitlán | - | CF Monterrey II | 1:1 | ||||
| 11. Jornada | 06.10.2021 | CF Monterrey II | - | Coyotes de Tlaxcala | 4:1 | |
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| 12. Jornada | 16.10.2021 | Dorados de Sinaloa | - | CF Monterrey II | 4:1 | |
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| 13. Jornada | 20.10.2021 | CF Monterrey II | - | Leones Negros | 0:1 | |
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| 15. Jornada | 07.11.2021 | CF Monterrey II | - | Pumas Tabasco | 1:1 | |
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| 16. Jornada | 11.11.2021 | Correcaminos UAT | - | CF Monterrey II | 2:1 | ||||
| 17. Jornada | 17.11.2021 | CF Monterrey II | - | Atlético Morelia | 0:1 |
México