| 1. Jornada | 07.01.2022 | Pumas Tabasco | - | CF Monterrey II | 0:1 |  |
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| 2. Jornada | 12.01.2022 | CF Monterrey II | - | Cimarrones de Sonora | 1:0 | ||||
| 3. Jornada | 24.01.2022 | Atlético Morelia | - | CF Monterrey II | 1:0 | ||||
| 4. Jornada | 27.01.2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 | |
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| 5. Jornada | 30.01.2022 | Club Celaya | - | CF Monterrey II | 2:1 | ||||
| 6. Jornada | 03.02.2022 | CF Monterrey II | - | Atlante | 0:1 |  |
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| 7. Jornada | 10.02.2022 | Mineros de Zacatecas | - | CF Monterrey II | 1:0 | ||||
| 8. Jornada | 16.02.2022 | CF Monterrey II | - | Correcaminos UAT | 3:3 | |
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| 9. Jornada | 24.02.2022 | Cancún FC | - | CF Monterrey II | 0:0 | ||||
| 10. Jornada | 03.03.2022 | CF Monterrey II | - | Venados FC | 3:3 | |
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| 11. Jornada | 09.03.2022 | TM Fútbol Club | - | CF Monterrey II | 0:0 | ||||
| 13. Jornada | 24.03.2022 | Leones Negros | - | CF Monterrey II | 0:0 | ||||
| 15. Jornada | 31.03.2022 | Coyotes de Tlaxcala | - | CF Monterrey II | 2:1 | |
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| 16. Jornada | 08.04.2022 | CF Monterrey II | - | Tepatitlán | 0:2 | ||||
| 12. Jornada | 10.04.2022 | CF Monterrey II | - | Dorados de Sinaloa | 0:1 | ||||
| 17. Jornada | 16.04.2022 | Tapatío | - | CF Monterrey II | 1:2 | |
México