| 2. Jornada | 29.01.2016 | Club Rubio Ñu | - | Club Nacional | 2:1 |  |
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| 3. Jornada | 03.02.2016 | Deportivo Capiatá | - | Club Rubio Ñu | 2:2 | ||||
| 4. Jornada | 07.02.2016 | Club Rubio Ñu | - | General Díaz | 0:0 | ||||
| 5. Jornada | 13.02.2016 | Cerro Porteño | - | Club Rubio Ñu | 1:2 | ||||
| 7. Jornada | 27.02.2016 | General Caballero ZC | - | Club Rubio Ñu | 0:1 |  |
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| 8. Jornada | 01.03.2016 | Club Rubio Ñu | - | Guaraní | 2:2 | ||||
| 9. Jornada | 05.03.2016 | River Plate | - | Club Rubio Ñu | 1:4 | ||||
| 10. Jornada | 13.03.2016 | Club Olimpia | - | Club Rubio Ñu | 4:1 | ||||
| 11. Jornada | 19.03.2016 | Club Rubio Ñu | - | Sol de América | 0:2 | |
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| 1. Jornada | 27.03.2016 | Libertad | - | Club Rubio Ñu | 0:1 | ||||
| 13. Jornada | 07.04.2016 | Club Nacional | - | Club Rubio Ñu | 3:1 | |
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| 14. Jornada | 10.04.2016 | Club Rubio Ñu | - | Deportivo Capiatá | 1:2 | |
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| 15. Jornada | 15.04.2016 | General Díaz | - | Club Rubio Ñu | 0:2 |
Paraguay