| Liga MX | 23.01.21 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
| Liga MX | 15.02.21 | Santos Laguna | - | CF Monterrey | 1:0 |  |
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| Liga MX | 14.03.21 | Club Tijuana | - | Santos Laguna | 0:1 | ||||
| Liga MX | 20.09.21 | Santos Laguna | - | Puebla FC | 1:1 | ||||
| Liga MX | 21.11.21 | Santos Laguna | - | Atlético San Luis | 2:0 | ||||
| Liga MX | 16.01.22 | Deportivo Toluca | - | Santos Laguna | 3:1 |
Colombia