| 1. Jornada | 17.01.2010 | CF América | - | Club San Luis | 5:1 |  |
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| 2. Jornada | 24.01.2010 | Atlante | - | Club San Luis | 2:3 | ||||
| 3. Jornada | 31.01.2010 | Club San Luis | - | Monarcas Morelia | 0:2 | ||||
| 4. Jornada | 07.02.2010 | CF Pachuca | - | Club San Luis | 2:0 | ||||
| 5. Jornada | 14.02.2010 | Club San Luis | - | Indios Juárez | 1:1 | ||||
| 6. Jornada | 18.02.2010 | Puebla FC | - | Club San Luis | 1:0 | ||||
| 11. Jornada | 21.03.2010 | Club San Luis | - | Deportivo Toluca | 2:3 | |
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| 12. Jornada | 28.03.2010 | Pumas UNAM | - | Club San Luis | 0:0 | |
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| 13. Jornada | 04.04.2010 | Club San Luis | - | UANL Tigres | 0:3 | |
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| 14. Jornada | 11.04.2010 | CF Monterrey | - | Club San Luis | 1:1 | ||||
| 15. Jornada | 15.04.2010 | Club San Luis | - | Estudiantes Tecos | 1:1 | ||||
| 16. Jornada | 20.04.2010 | Santos Laguna | - | Club San Luis | 2:1 | ||||
| 17. Jornada | 25.04.2010 | Club San Luis | - | Gallos Blancos (old) | 3:0 |
Uruguay