| 1. Jornada | 06.01.2022 | Atlético San Luis [Sub 18] | - | CF Pachuca [Sub 18] | 1:0 | ||||
| 2. Jornada | 16.01.2022 | CF Pachuca [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 4:2 | ||||
| 3. Jornada | 22.01.2022 | Club León [Sub 18] | - | CF Pachuca [Sub 18] | 4:2 | ||||
| 4. Jornada | 05.02.2022 | Club Necaxa [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 | ||||
| 16. Jornada | 23.04.2022 | CF Pachuca [Sub 18] | - | CF Monterrey [Sub 18] | 2:1 |  |
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| 17. Jornada | 01.05.2022 | Pumas UNAM [Sub 18] | - | CF Pachuca [Sub 18] | 0:1 |
México