| 2. Jornada | 22.01.2022 | Alacranes de Durango | - | Saltillo FC | 3:1 |  |
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| 3. Jornada | 29.01.2022 | Saltillo FC | - | Cimarrones de Sonora II | 2:1 | ||||
| 10. Jornada | 19.03.2022 | Saltillo FC | - | Colima FC | 2:1 | ||||
| 11. Jornada | 26.03.2022 | Leones Negros II | - | Saltillo FC | 2:1 | ||||
| 13. Jornada | 10.04.2022 | Mineros de Fresnillo FC | - | Saltillo FC | 0:5 |
Argentina