| 5. Jornada | 09.10.2021 | Progreso | - | River Plate | 1:0 |  |
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| 7. Jornada | 20.10.2021 | Plaza Colonia | - | River Plate | 0:0 | ||||
| 9. Jornada | 30.10.2021 | Boston River | - | River Plate | 1:2 | ||||
| 10. Jornada | 03.11.2021 | River Plate | - | Montevideo Wanderers | 0:1 | ||||
| 12. Jornada | 14.11.2021 | River Plate | - | Peñarol | 1:1 | ||||
| 13. Jornada | 22.11.2021 | Montevideo City Torque | - | River Plate | 1:1 | ||||
| 14. Jornada | 30.11.2021 | River Plate | - | Villa Española | 4:2 | ||||
| 15. Jornada | 04.12.2021 | Nacional | - | River Plate | 4:2 |
Uruguay