| 1. Jornada | 15.07.2022 | Resistencia SC | - | Sol de América | 2:1 | ||||
| 2. Jornada | 21.07.2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
| 3. Jornada | 26.07.2022 | Resistencia SC | - | Guaraní | 0:0 | ||||
| 4. Jornada | 31.07.2022 | Libertad | - | Resistencia SC | 4:0 | ||||
| 6. Jornada | 16.08.2022 | Tacuary | - | Resistencia SC | 1:1 |  |
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| 7. Jornada | 19.08.2022 | Resistencia SC | - | Sportivo Ameliano | 2:1 | ||||
| 8. Jornada | 28.08.2022 | Club Olimpia | - | Resistencia SC | 1:1 | ||||
| 9. Jornada | 03.09.2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
| 10. Jornada | 10.09.2022 | Resistencia SC | - | Cerro Porteño | 0:2 | ||||
| 13. Jornada | 25.09.2022 | Resistencia SC | - | Club Nacional | 0:1 |  |
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| 14. Jornada | 04.10.2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
| 15. Jornada | 06.10.2022 | Resistencia SC | - | Libertad | 1:0 | ||||
| 16. Jornada | 10.10.2022 | Guaireña FC | - | Resistencia SC | 3:2 | ||||
| 17. Jornada | 15.10.2022 | Resistencia SC | - | Tacuary | 0:3 | ||||
| 18. Jornada | 22.10.2022 | Sportivo Ameliano | - | Resistencia SC | 3:2 | |
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| 19. Jornada | 27.10.2022 | Resistencia SC | - | Club Olimpia | 1:6 |
Paraguay