| 1. Jornada | 22.01.2020 | Blooming | - | Real Santa Cruz | 1:1 |  |
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| 2. Jornada | 27.01.2020 | Real Santa Cruz | - | The Strongest | 3:2 | |
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| 4. Jornada | 02.02.2020 | Real Potosí | - | Real Santa Cruz | 2:1 | ||||
| 3. Jornada | 05.02.2020 | Real Santa Cruz | - | Club San José | 1:1 | |
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| 6. Jornada | 14.02.2020 | Jorge Wilstermann | - | Real Santa Cruz | 0:0 | |
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| 7. Jornada | 16.02.2020 | Real Santa Cruz | - | Oriente Petrolero | 1:5 | |
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| 9. Jornada | 27.02.2020 | Real Santa Cruz | - | Bolívar | 2:4 | |
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| 10. Jornada | 03.03.2020 | Royal Pari | - | Real Santa Cruz | 0:2 | ||||
| 11. Jornada | 06.03.2020 | Real Santa Cruz | - | Nacional Potosí | 2:1 | ||||
| 12. Jornada | 15.03.2020 | CD Guabirá | - | Real Santa Cruz | 1:0 | |
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| 15. Jornada | 03.12.2020 | The Strongest | - | Real Santa Cruz | 4:2 | ||||
| 16. Jornada | 07.12.2020 | Club San José | - | Real Santa Cruz | 4:1 | ||||
| 17. Jornada | 09.12.2020 | Real Santa Cruz | - | Real Potosí | 3:1 | ||||
| 18. Jornada | 12.12.2020 | Real Santa Cruz | - | Always Ready | 0:3 | ||||
| 24. Jornada | 27.12.2020 | Nacional Potosí | - | Real Santa Cruz | 1:0 | ||||
| 25. Jornada | 29.12.2020 | Real Santa Cruz | - | CD Guabirá | 4:4 | |
Bolivia