| 2. Jornada | 16.01.2022 | Atlas Guadalajara | - | Atlético San Luis | 1:0 |  |
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| 3. Jornada | 21.01.2022 | Atlético San Luis | - | FC Juárez | 0:1 | |
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| 4. Jornada | 06.02.2022 | CF América | - | Atlético San Luis | 2:3 | |
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| 5. Jornada | 13.02.2022 | Atlético San Luis | - | Deportivo Toluca | 0:1 | ||||
| 6. Jornada | 20.02.2022 | UANL Tigres | - | Atlético San Luis | 2:1 |  |
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| 8. Jornada | 03.03.2022 | Atlético San Luis | - | Deportivo Guadalajara | 2:2 | ||||
| 10. Jornada | 14.03.2022 | Atlético San Luis | - | Puebla FC | 2:1 |  |
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| 11. Jornada | 18.03.2022 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Jornada | 02.04.2022 | Atlético San Luis | - | Mazatlán FC | 1:0 | ||||
| 9. Jornada | 07.04.2022 | Club Tijuana | - | Atlético San Luis | 1:1 | ||||
| 13. Jornada | 10.04.2022 | Atlético San Luis | - | Club León | 2:0 | |
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| 14. Jornada | 16.04.2022 | Club Necaxa | - | Atlético San Luis | 4:2 | ||||
| 15. Jornada | 21.04.2022 | Atlético San Luis | - | Pumas UNAM | 2:0 | ||||
| 16. Jornada | 25.04.2022 | Cruz Azul | - | Atlético San Luis | 0:1 |
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