| 1. Jornada | 07.01.2023 | Club Necaxa | - | Atlético San Luis | 2:3 |  |
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| 2. Jornada | 14.01.2023 | Atlético San Luis | - | Deportivo Guadalajara | 0:0 |  |
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| 4. Jornada | 29.01.2023 | UANL Tigres | - | Atlético San Luis | 0:0 | ||||
| 5. Jornada | 03.02.2023 | Atlético San Luis | - | Puebla FC | 2:0 | ||||
| 6. Jornada | 11.02.2023 | Club Tijuana | - | Atlético San Luis | 1:0 | ||||
| 7. Jornada | 15.02.2023 | Atlético San Luis | - | CF América | 1:3 | ||||
| 8. Jornada | 19.02.2023 | Atlético San Luis | - | Santos Laguna | 1:1 | ||||
| 10. Jornada | 05.03.2023 | Club León | - | Atlético San Luis | 2:0 | ||||
| 11. Jornada | 11.03.2023 | Atlético San Luis | - | Gallos Blancos | 2:0 |  |
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| 12. Jornada | 19.03.2023 | Cruz Azul | - | Atlético San Luis | 1:0 | ||||
| 13. Jornada | 03.04.2023 | Atlético San Luis | - | Mazatlán FC | 2:1 | ||||
| 14. Jornada | 09.04.2023 | Pumas UNAM | - | Atlético San Luis | 3:1 | ||||
| 15. Jornada | 14.04.2023 | Atlético San Luis | - | FC Juárez | 2:0 | |
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| 16. Jornada | 23.04.2023 | CF Pachuca | - | Atlético San Luis | 2:1 | |
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| 17. Jornada | 30.04.2023 | Atlético San Luis | - | Atlas Guadalajara | 0:0 |
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