| 3. Jornada | 21.02.2022 | Newell's Old Boys | - | River Plate | 0:2 | ||||
| 5. Jornada | 06.03.2022 | Newell's Old Boys | - | Atlético Tucumán | 4:0 |  |
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| 6. Jornada | 12.03.2022 | Sarmiento de Junín | - | Newell's Old Boys | 2:2 |  |
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| 7. Jornada | 20.03.2022 | Rosario Central | - | Newell's Old Boys | 0:1 | ||||
| 8. Jornada | 04.04.2022 | Newell's Old Boys | - | Platense | 3:1 | ||||
| 9. Jornada | 09.04.2022 | Unión de Santa Fe | - | Newell's Old Boys | 1:0 | |
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| 10. Jornada | 16.04.2022 | Newell's Old Boys | - | Patronato de Paraná | 1:0 | ||||
| 11. Jornada | 20.04.2022 | Newell's Old Boys | - | Banfield | 1:0 | ||||
| 12. Jornada | 24.04.2022 | Racing Club | - | Newell's Old Boys | 0:0 | ||||
| 14. Jornada | 08.05.2022 | Gimnasia de La Plata | - | Newell's Old Boys | 3:1 |
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