| 1. Jornada | 17.07.2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 | ||||
| 2. Jornada | 27.07.2021 | Argentinos Juniors | - | Newell's Old Boys | 1:0 | ||||
| 3. Jornada | 30.07.2021 | Newell's Old Boys | - | Estudiantes | 4:2 | ||||
| 4. Jornada | 02.08.2021 | Patronato de Paraná | - | Newell's Old Boys | 0:0 |  |
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| 5. Jornada | 07.08.2021 | Newell's Old Boys | - | Platense | 1:0 | ||||
| 6. Jornada | 16.08.2021 | Racing Club | - | Newell's Old Boys | 2:0 | ||||
| 7. Jornada | 22.08.2021 | Newell's Old Boys | - | Rosario Central | 1:1 | |
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| 10. Jornada | 04.09.2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 | ||||
| 12. Jornada | 20.09.2021 | CA Lanús | - | Newell's Old Boys | 1:2 | ||||
| 13. Jornada | 28.09.2021 | Newell's Old Boys | - | Huracán | 0:1 | |
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| 14. Jornada | 02.10.2021 | Godoy Cruz | - | Newell's Old Boys | 2:2 | |
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| 15. Jornada | 09.10.2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 | |
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