| 5. Jornada | 24.04.2021 | Club San José | - | CD Guabirá | 0:1 |  |
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| 6. Jornada | 04.05.2021 | Blooming | - | Club San José | 4:0 | |
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| 7. Jornada | 08.05.2021 | Club San José | - | Bolívar | 0:5 | |
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| 11. Jornada | 26.07.2021 | Real Santa Cruz | - | Club San José | 5:0 | ||||
| 13. Jornada | 05.08.2021 | Oriente Petrolero | - | Club San José | 4:0 | ||||
| 14. Jornada | 07.08.2021 | Club San José | - | The Strongest | 0:1 | |
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| 15. Jornada | 15.08.2021 | Jorge Wilstermann | - | Club San José | 4:0 | ||||
| 16. Jornada | 19.08.2021 | Atlético Palmaflor | - | Club San José | 1:0 | ||||
| 17. Jornada | 21.08.2021 | Club San José | - | Always Ready | 0:4 | ||||
| 18. Jornada | 11.09.2021 | Royal Pari | - | Club San José | 6:1 | ||||
| 19. Jornada | 17.09.2021 | Club San José | - | Real Potosí | 0:0 | |
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| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | |
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| 24. Jornada | 28.10.2021 | Real Tomayapo | - | Club San José | 1:0 | ||||
| 25. Jornada | 01.11.2021 | Independiente Petrolero | - | Club San José | 4:0 | ||||
| 26. Jornada | 22.11.2021 | Club San José | - | Real Santa Cruz | 1:2 | ||||
| 27. Jornada | 26.11.2021 | Nacional Potosí | - | Club San José | 7:1 | ||||
| 28. Jornada | 30.11.2021 | Club San José | - | Oriente Petrolero | 0:2 |
Bolivia