| 1. Jornada | 18.04.2021 | Nashville SC | - | FC Cincinnati | 2:2 | ||||
| 1. Jornada | 24.04.2021 | New York City FC | - | FC Cincinnati | 5:0 | ||||
| 2. Jornada | 02.05.2021 | Orlando City | - | FC Cincinnati | 3:0 | ||||
| 2. Jornada | 16.05.2021 | FC Cincinnati | - | Inter Miami CF | 2:3 | ||||
| 2. Jornada | 22.05.2021 | CF Montréal | - | FC Cincinnati | 1:2 |  |
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| 2. Jornada | 29.05.2021 | FC Cincinnati | - | New England Revolution | 0:1 | ||||
| 3. Jornada | 20.06.2021 | FC Cincinnati | - | Colorado Rapids | 0:2 | ||||
| 3. Jornada | 24.06.2021 | Chicago Fire | - | FC Cincinnati | 0:1 | ||||
| 3. Jornada | 27.06.2021 | Toronto FC | - | FC Cincinnati | 0:2 |
Países Bajos