| 1. Jornada | 14.08.2021 | Floriana FC | - | St. Luċija FC | 2:2 |  |
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| 2. Jornada | 22.08.2021 | St. Luċija FC | - | Gżira United | 1:1 | ||||
| 3. Jornada | 12.09.2021 | Gudja United | - | St. Luċija FC | 2:2 | ||||
| 4. Jornada | 18.09.2021 | St. Luċija FC | - | Sirens FC | 1:3 | ||||
| 5. Jornada | 25.09.2021 | Hibernians FC | - | St. Luċija FC | 1:1 | |
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| 6. Jornada | 17.10.2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 7. Jornada | 24.10.2021 | St. Luċija FC | - | Sliema Wanderers | 0:0 | ||||
| 8. Jornada | 30.10.2021 | Valletta FC | - | St. Luċija FC | 5:3 | ||||
| 9. Jornada | 21.11.2021 | St. Luċija FC | - | Birkirkara FC | 2:0 | |
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| 10. Jornada | 28.11.2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | ||||
| 11. Jornada | 05.12.2021 | St. Luċija FC | - | Balzan FC | 3:3 | ||||
| 12. Jornada | 11.12.2021 | St. Luċija FC | - | Floriana FC | 1:3 | ||||
| 13. Jornada | 18.12.2021 | Gżira United | - | St. Luċija FC | 2:2 |
San Cristóbal y Nieves