| 1. Jornada | 09.07.2022 | Real Santander | - | Llaneros FC | 3:1 | ||||
| 2. Jornada | 17.07.2022 | Deportes Quindío | - | Real Santander | 2:0 | ||||
| 3. Jornada | 23.07.2022 | Real Santander | - | Fortaleza FC | 1:0 | ||||
| 4. Jornada | 30.07.2022 | Real Santander | - | Atlético FC | 0:1 | ||||
| 5. Jornada | 05.08.2022 | Leones FC | - | Real Santander | 1:1 |  |
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| 6. Jornada | 08.08.2022 | Real Santander | - | Bogotá FC | 2:0 | |
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| 7. Jornada | 17.08.2022 | Real Cartagena | - | Real Santander | 2:2 | |
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| 8. Jornada | 20.08.2022 | Orsomarso SC | - | Real Santander | 0:0 | ||||
| 9. Jornada | 27.08.2022 | Real Santander | - | Cúcuta Deportivo | 0:1 | ||||
| 10. Jornada | 03.09.2022 | Tigres FC | - | Real Santander | 2:2 | ||||
| 11. Jornada | 07.09.2022 | Real Santander | - | Valledupar FC | 1:0 | |
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| 12. Jornada | 14.09.2022 | Barranquilla FC | - | Real Santander | 2:1 | ||||
| 13. Jornada | 19.09.2022 | Real Santander | - | Boyacá Chicó | 0:0 | ||||
| 14. Jornada | 23.09.2022 | Cúcuta Deportivo | - | Real Santander | 0:0 | ||||
| 15. Jornada | 03.10.2022 | Real Santander | - | Atlético Huila | 2:1 | |
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| 16. Jornada | 08.10.2022 | Boca Juniors de Cali | - | Real Santander | 2:3 | |
Colombia