| Grupo F | 14.05.2021 | Libertad | - | Newell's Old Boys | 1:0 | ||||
| Grupo F | 26.05.2021 | Palestino | - | Libertad | 1:2 | ||||
| Octavos de final | 15.07.2021 | Atlético Junior | - | Libertad | 3:4 |  |
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| Octavos de final | 22.07.2021 | Libertad | - | Atlético Junior | 0:1 | |
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| Cuartos de final | 13.08.2021 | Santos FC | - | Libertad | 2:1 | ||||
| Semifinales | 23.09.2021 | Red Bull Bragantino | - | Libertad | 2:0 | ||||
| Semifinales | 30.09.2021 | Libertad | - | Red Bull Bragantino | 1:3 |
Paraguay