| 1. Jornada | 06.02.2022 | 12 de Octubre de Itauguá | - | Libertad | 1:6 |  |
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| 2. Jornada | 13.02.2022 | Libertad | - | General Caballero DJLM | 1:0 | |
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| 3. Jornada | 21.02.2022 | Club Olimpia | - | Libertad | 2:2 | ||||
| 4. Jornada | 28.02.2022 | Tacuary | - | Libertad | 0:1 | |
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| 5. Jornada | 06.03.2022 | Libertad | - | Sportivo Ameliano | 2:0 | |
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| 6. Jornada | 15.03.2022 | Club Nacional | - | Libertad | 0:3 | ||||
| 7. Jornada | 20.03.2022 | Libertad | - | Guaraní | 2:0 | |
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| 8. Jornada | 03.04.2022 | Guaireña FC | - | Libertad | 2:3 | |
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| 9. Jornada | 11.04.2022 | Libertad | - | Sol de América | 3:1 | |
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| 10. Jornada | 18.04.2022 | Cerro Porteño | - | Libertad | 4:0 |  |
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| 11. Jornada | 21.04.2022 | Libertad | - | Resistencia SC | 2:2 | |
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| 12. Jornada | 23.04.2022 | Libertad | - | 12 de Octubre de Itauguá | 4:0 | ||||
| 13. Jornada | 30.04.2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
| 14. Jornada | 08.05.2022 | Libertad | - | Club Olimpia | 1:0 |
Paraguay