| 1. Jornada | 09.01.2021 | Mazatlán FC | - | Club Necaxa | 3:2 |  |
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| 2. Jornada | 16.01.2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
| 3. Jornada | 24.01.2021 | Deportivo Toluca | - | Club Necaxa | 2:0 | |
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| 4. Jornada | 29.01.2021 | UANL Tigres | - | Club Necaxa | 1:1 | |
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| 5. Jornada | 06.02.2021 | Club Necaxa | - | Cruz Azul | 0:2 | ||||
| 6. Jornada | 14.02.2021 | Deportivo Guadalajara | - | Club Necaxa | 2:2 | |
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| 7. Jornada | 20.02.2021 | Club Necaxa | - | CF Monterrey | 1:1 | |
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| 9. Jornada | 05.03.2021 | Club Necaxa | - | CF Pachuca | 2:2 | ||||
| 10. Jornada | 08.03.2021 | Santos Laguna | - | Club Necaxa | 3:1 | |
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| 11. Jornada | 16.03.2021 | Club León | - | Club Necaxa | 3:1 | ||||
| 14. Jornada | 10.04.2021 | Club Necaxa | - | Pumas UNAM | 0:1 | ||||
| 15. Jornada | 17.04.2021 | Club Necaxa | - | Gallos Blancos | 0:0 | ||||
| 16. Jornada | 24.04.2021 | Club Tijuana | - | Club Necaxa | 1:0 | ||||
| 17. Jornada | 01.05.2021 | Club Necaxa | - | Atlas Guadalajara | 1:5 |
Paraguay