| 1. Jornada | 24.07.2021 | Club Necaxa | - | Santos Laguna | 0:3 | ||||
| 2. Jornada | 01.08.2021 | CF América | - | Club Necaxa | 2:1 | ||||
| 3. Jornada | 07.08.2021 | Club Necaxa | - | Cruz Azul | 1:2 | ||||
| 4. Jornada | 13.08.2021 | Atlético San Luis | - | Club Necaxa | 0:2 |  |
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| 5. Jornada | 18.08.2021 | Club Necaxa | - | Pumas UNAM | 3:0 | ||||
| 6. Jornada | 23.08.2021 | Club Necaxa | - | FC Juárez | 1:0 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Guadalajara | - | Club Necaxa | 2:1 | ||||
| 8. Jornada | 13.09.2021 | Gallos Blancos | - | Club Necaxa | 3:0 | ||||
| 9. Jornada | 18.09.2021 | Club Necaxa | - | Atlas Guadalajara | 0:3 | ||||
| 11. Jornada | 29.09.2021 | Club Necaxa | - | Club Tijuana | 3:0 | ||||
| 12. Jornada | 04.10.2021 | UANL Tigres | - | Club Necaxa | 0:0 | ||||
| 13. Jornada | 16.10.2021 | Club Necaxa | - | Puebla FC | 0:1 | ||||
| 14. Jornada | 21.10.2021 | Deportivo Toluca | - | Club Necaxa | 1:1 | |
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| 15. Jornada | 24.10.2021 | CF Monterrey | - | Club Necaxa | 0:1 | ||||
| 16. Jornada | 30.10.2021 | Club Necaxa | - | Mazatlán FC | 2:1 | ||||
| 17. Jornada | 07.11.2021 | Club León | - | Club Necaxa | 3:0 |
Paraguay