| 2. Jornada | 15.03.2021 | Blooming | - | Independiente Petrolero | 2:2 |  |
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| 3. Jornada | 03.04.2021 | Bolívar | - | Blooming | 2:0 | |
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| 4. Jornada | 10.04.2021 | Blooming | - | Club Aurora | 1:0 | ||||
| 6. Jornada | 04.05.2021 | Blooming | - | Club San José | 4:0 | ||||
| 8. Jornada | 13.07.2021 | Blooming | - | Nacional Potosí | 2:1 | |
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| 9. Jornada | 18.07.2021 | Oriente Petrolero | - | Blooming | 3:0 | ||||
| 10. Jornada | 22.07.2021 | Blooming | - | The Strongest | 2:0 | ||||
| 11. Jornada | 27.07.2021 | Jorge Wilstermann | - | Blooming | 2:1 | ||||
| 12. Jornada | 31.07.2021 | Blooming | - | Atlético Palmaflor | 1:1 | ||||
| 13. Jornada | 04.08.2021 | Always Ready | - | Blooming | 5:1 | ||||
| 14. Jornada | 10.08.2021 | Blooming | - | Royal Pari | 0:1 | |
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| 16. Jornada | 18.08.2021 | CD Guabirá | - | Blooming | 4:2 | ||||
| 17. Jornada | 22.08.2021 | Independiente Petrolero | - | Blooming | 3:0 | ||||
| 18. Jornada | 15.09.2021 | Blooming | - | Bolívar | 2:2 | ||||
| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | ||||
| 22. Jornada | 18.10.2021 | Blooming | - | Real Santa Cruz | 3:1 | ||||
| 24. Jornada | 28.10.2021 | Blooming | - | Oriente Petrolero | 1:1 | ||||
| 29. Jornada | 05.12.2021 | Royal Pari | - | Blooming | 4:3 |  |
Bolivia