| 4. Jornada | 24.06.2012 | Chicago Fire | - | Columbus Crew | 2:1 | ||||
| 4. Jornada | 01.07.2012 | Columbus Crew | - | Real Salt Lake | 2:0 | ||||
| 5. Jornada | 22.07.2012 | Columbus Crew | - | D.C. United | 1:0 | ||||
| 5. Jornada | 29.07.2012 | Sporting Kansas City | - | Columbus Crew | 1:2 | ||||
| 6. Jornada | 23.08.2012 | Columbus Crew | - | Toronto FC | 2:1 | ||||
| 6. Jornada | 26.08.2012 | Columbus Crew | - | New England Revolution | 4:3 | ||||
| 6. Jornada | 30.08.2012 | Philadelphia Union | - | Columbus Crew | 1:2 | ||||
| 7. Jornada | 16.09.2012 | New York RB | - | Columbus Crew | 3:1 |  |
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| 7. Jornada | 20.09.2012 | Columbus Crew | - | CD Chivas | 1:0 | ||||
| 7. Jornada | 23.09.2012 | Chicago Fire | - | Columbus Crew | 2:1 | ||||
| 7. Jornada | 30.09.2012 | Columbus Crew | - | Philadelphia Union | 3:2 | ||||
| 8. Jornada | 07.10.2012 | Columbus Crew | - | Sporting Kansas City | 1:1 | |
Trinidad y Tobago