| 6. Jornada | 03.04.2022 | Guayaquil City | - | Técnico Universitario | 0:1 | ||||
| 7. Jornada | 10.04.2022 | Independiente del Valle | - | Guayaquil City | 0:0 | ||||
| 8. Jornada | 17.04.2022 | Guayaquil City | - | Aucas | 4:0 |  |
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| 11. Jornada | 30.04.2022 | Mushuc Runa | - | Guayaquil City | 2:0 | ||||
| 12. Jornada | 09.05.2022 | Guayaquil City | - | Barcelona | 1:4 | ||||
| 9. Jornada | 12.05.2022 | 9 de Octubre | - | Guayaquil City | 2:2 | ||||
| 13. Jornada | 17.05.2022 | Gualaceo SC | - | Guayaquil City | 2:1 | ||||
| 14. Jornada | 22.05.2022 | Guayaquil City | - | LDU Quito | 2:2 | ||||
| 15. Jornada | 28.05.2022 | Orense SC | - | Guayaquil City | 0:1 |
Ecuador