| 2. Jornada | 13.03.2022 | Portland Timbers | - | Austin FC | 1:0 | ||||
| 2. Jornada | 20.03.2022 | FC Dallas | - | Portland Timbers | 4:1 | ||||
| 3. Jornada | 03.04.2022 | Portland Timbers | - | Los Angeles Galaxy | 1:3 | ||||
| 4. Jornada | 01.05.2022 | Colorado Rapids | - | Portland Timbers | 2:0 | ||||
| 4. Jornada | 08.05.2022 | New York RB | - | Portland Timbers | 1:1 | ||||
| 4. Jornada | 15.05.2022 | Portland Timbers | - | Sporting Kansas City | 7:2 | ||||
| 4. Jornada | 19.05.2022 | San Jose Earthquakes | - | Portland Timbers | 3:2 |  |
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| 4. Jornada | 23.05.2022 | Portland Timbers | - | Philadelphia Union | 0:2 | ||||
| 4. Jornada | 29.05.2022 | Inter Miami CF | - | Portland Timbers | 2:1 |
Estados Unidos