| 1. Jornada | 11.02.2022 | Newell's Old Boys | - | Defensa y Justicia | 1:0 | ||||
| 2. Jornada | 15.02.2022 | Argentinos Juniors | - | Newell's Old Boys | 3:0 |  |
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| 8. Jornada | 04.04.2022 | Newell's Old Boys | - | Platense | 3:1 | |
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| 9. Jornada | 09.04.2022 | Unión de Santa Fe | - | Newell's Old Boys | 1:0 | |
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| 10. Jornada | 16.04.2022 | Newell's Old Boys | - | Patronato de Paraná | 1:0 | |
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| 11. Jornada | 20.04.2022 | Newell's Old Boys | - | Banfield | 1:0 | ||||
| 12. Jornada | 24.04.2022 | Racing Club | - | Newell's Old Boys | 0:0 | ||||
| 13. Jornada | 28.04.2022 | Newell's Old Boys | - | San Lorenzo | 1:2 | |
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