| Octavos de final | 08.04.2021 | Deportivo Saprissa | - | Philadelphia Union | 0:1 | ||||
| Octavos de final | 15.04.2021 | Philadelphia Union | - | Deportivo Saprissa | 4:0 | ||||
| Cuartos de final | 28.04.2021 | Atlanta United FC | - | Philadelphia Union | 0:3 | ||||
| Cuartos de final | 05.05.2021 | Philadelphia Union | - | Atlanta United FC | 1:1 | ||||
| Semifinales | 13.08.2021 | CF América | - | Philadelphia Union | 2:0 | ||||
| Semifinales | 16.09.2021 | Philadelphia Union | - | CF América | 0:2 |  |
Alemania