| 1. Jornada | 28.07.2021 | Real Cartagena | - | Valledupar FC | 2:2 | ||||
| 2. Jornada | 03.08.2021 | Boyacá Chicó | - | Real Cartagena | 1:0 | ||||
| 3. Jornada | 06.08.2021 | Real Cartagena | - | Fortaleza FC | 0:1 |  |
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| 4. Jornada | 14.08.2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
| 9. Jornada | 19.09.2021 | Leones FC | - | Real Cartagena | 2:0 | |
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| 10. Jornada | 29.09.2021 | Real Cartagena | - | Llaneros FC | 2:1 | ||||
| 11. Jornada | 06.10.2021 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 12. Jornada | 12.10.2021 | Real Cartagena | - | Barranquilla FC | 3:1 | |
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| 13. Jornada | 20.10.2021 | Bogotá FC | - | Real Cartagena | 0:0 | ||||
| 14. Jornada | 26.10.2021 | Real Cartagena | - | Atlético FC | 1:1 | |
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| 15. Jornada | 30.10.2021 | Orsomarso SC | - | Real Cartagena | 1:1 |
Colombia