| 1. Jornada | 18.04.2021 | Nashville SC | - | FC Cincinnati | 2:2 |  |
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| 1. Jornada | 24.04.2021 | New York City FC | - | FC Cincinnati | 5:0 | ||||
| 2. Jornada | 02.05.2021 | Orlando City | - | FC Cincinnati | 3:0 | ||||
| 4. Jornada | 25.07.2021 | Nashville SC | - | FC Cincinnati | 3:0 | ||||
| 5. Jornada | 22.08.2021 | New England Revolution | - | FC Cincinnati | 4:1 | ||||
| 6. Jornada | 05.09.2021 | FC Cincinnati | - | Inter Miami CF | 0:1 | ||||
| 6. Jornada | 26.09.2021 | D.C. United | - | FC Cincinnati | 4:2 | ||||
| 7. Jornada | 03.10.2021 | FC Cincinnati | - | New York RB | 0:1 | ||||
| 7. Jornada | 10.10.2021 | FC Cincinnati | - | Philadelphia Union | 1:2 | ||||
| 7. Jornada | 17.10.2021 | FC Cincinnati | - | Orlando City | 0:1 | ||||
| 7. Jornada | 21.10.2021 | FC Cincinnati | - | Chicago Fire | 3:4 | ||||
| 7. Jornada | 24.10.2021 | Inter Miami CF | - | FC Cincinnati | 5:1 | ||||
| 7. Jornada | 28.10.2021 | FC Cincinnati | - | Nashville SC | 3:6 |
Sudáfrica
Países Bajos