| 7. Jornada | 26.02.2022 | Pumas UNAM [Sub 20] | - | CF América [Sub 20] | 0:1 | ||||
| 8. Jornada | 01.03.2022 | CF América [Sub 20] | - | Gallos Blancos [Sub 20] | 2:0 |  |
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| 10. Jornada | 12.03.2022 | Deportivo Guadalajara [Sub 20] | - | CF América [Sub 20] | 0:2 | ||||
| 12. Jornada | 02.04.2022 | Club Necaxa [Sub 20] | - | CF América [Sub 20] | 1:2 | ||||
| 14. Jornada | 16.04.2022 | Club Tijuana [Sub 20] | - | CF América [Sub 20] | 4:0 | ||||
| 16. Jornada | 23.04.2022 | UANL Tigres [Sub 20] | - | CF América [Sub 20] | 3:1 |
México