| 1. Jornada | 16.07.2022 | Spartak Trnava | - | Zlaté Moravce | 2:0 |  |
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| 2. Jornada | 24.07.2022 | Spartak Trnava | - | Dukla Banská Bystrica | 1:2 | |
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| 3. Jornada | 31.07.2022 | Spartak Trnava | - | FK Železiarne Podbrezová | 1:1 | ||||
| 4. Jornada | 07.08.2022 | Spartak Trnava | - | MŠK Žilina | 2:2 |  |
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| 5. Jornada | 14.08.2022 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:4 | ||||
| 6. Jornada | 20.08.2022 | Spartak Trnava | - | FC DAC 1904 | 3:1 | ||||
| 7. Jornada | 27.08.2022 | MFK Skalica | - | Spartak Trnava | 1:1 | ||||
| 8. Jornada | 31.08.2022 | Spartak Trnava | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 9. Jornada | 04.09.2022 | MFK Ružomberok | - | Spartak Trnava | 3:2 | ||||
| 10. Jornada | 11.09.2022 | AS Trenčín | - | Spartak Trnava | 0:2 | ||||
| 11. Jornada | 18.09.2022 | Spartak Trnava | - | Slovan Bratislava | 0:0 | ||||
| 14. Jornada | 16.10.2022 | FK Železiarne Podbrezová | - | Spartak Trnava | 3:1 | ||||
| 15. Jornada | 22.10.2022 | MŠK Žilina | - | Spartak Trnava | 1:2 | ||||
| 17. Jornada | 05.11.2022 | FC DAC 1904 | - | Spartak Trnava | 1:0 | ||||
| 18. Jornada | 11.11.2022 | Spartak Trnava | - | MFK Skalica | 2:1 | ||||
| 16. Jornada | 24.11.2022 | Spartak Trnava | - | MFK Zemplín Michalovce | 4:1 |
Ghana